Tamoxifen Demonstrates Benefits in Muscular Dystrophy. This conclusion was made by scientists from Stanford..

Breast cancer drug tamoxifen improved heart muscle cell function and survival in cell models of Duchenne muscular dystrophy. With this pathology, the body is not able to produce the protein dystrophin, which usually helps muscle cells to touch each other during movement.. Because of this, the muscles are severely damaged, all this negatively affects the entire skeletal muscles and the muscles of the heart.. One of the leading causes of death in patients with this disease is a disease called dilated cardiomyopathy..

Recent evidence suggests that tamoxifen may help protect cells from damage.. Now the drug is actively used to treat certain types of breast cancer, it modulates the activity of protein receptors for the hormone estrogen.. These receptors are expressed on many cells throughout the body, including muscle cells.. A recent study showed that tamoxifen use did not significantly slow motor deterioration in boys with Duchenne muscular dystrophy compared with a placebo group..

Researchers at Stanford University conducted a series of experiments using cardiomyocytes derived from induced human pluripotent stem cells.. These cell models have provided the opportunity to test tamoxifen, and observations have shown that it improves the function and survival of this category of cells.. So, the drug has the ability to help patients with muscular dystrophy.

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