Brown adipose tissue (brown fat) is “good” adipose tissue that is involved in burning nutrients and generating energy, according to Pannochka, an online publication for girls and women from 14 to 35 years old.. net A recent study showed that obese people have less brown fat, but scientists didn't know why.

It has now been found that obese patients have elevated levels of a specific hormone that inhibits the activity of brown adipose tissue, increasing the risk of diabetes and metabolic disorders..

Researchers at the Michael DeGroot School of Medicine, led by Professor Gregory Steinberg, director of the Metabolism and Childhood Obesity Program at McMaster University (Ontario, Canada), have published their findings in the journal Nature Medicine..

Scientists say that there are two types of serotonin - a biologically active substance that plays the role of a neurotransmitter that transmits signals from one area of \u200b\u200bthe brain to another. Although most people are familiar with the effect of serotonin on mood and appetite, this type of serotonin is only 5% of its reserves in the body..

The remaining 95% is the so-called peripheral serotonin, which circulates throughout the body.. Scientists say this substance reduces the activity of brown adipose tissue. In the first study to address this issue, scientists have shown that blocking peripheral serotonin dramatically increases brown fat activity..

“Our results are amazing. Suppression of peripheral serotonin synthesis can be a very effective treatment for obesity and its associated metabolic disorders,” writes Prof. Steinberg in his article..

Tph1 suppression in mice improves brown fat's calorie-burning ability.

The professor and his colleagues note that most of the serotonin in the body is synthesized by an enzyme called tryptophan hydroxylase (Tph1).

When scientists fed mice genetically deficient in Tph1 with a fatty diet, they increased the ability of brown adipose tissue to burn calories, which protects rodents from obesity, fatty liver disease and prediabetes.. No need to explain what would happen to normal mice if they were put on such a diet..

A few facts about brown fat:.

• Brown fat generates heat.

• Mammals with more brown fat are less cold.

• Brown fat is mostly concentrated in the neck Study co-author Waliul Khan, professor at McMaster University School of Medicine, notes that a fatty Western diet is a serious external factor that increases peripheral serotonin levels in the body..

“Too much cholesterol is just as bad as too little.”. Need a balance. Too much of it leads to diabetes, fatty liver disease, and obesity,” Khan writes.. Professor Steinberg explains that excess peripheral serotonin acts as a "

The scientist adds that the suppression of peripheral serotonin will not affect brain serotonin, that is, it will not lead to disorders of the central nervous system.. Early weight loss drugs that suppressed appetite, on the contrary, disrupted the level of serotonin in the brain.

Such drugs have led to depression, suicidal thoughts, cardiovascular events, so they have been banned in many countries.. To be fair, it should be noted that they really suppressed appetite and increased energy expenditure..

Today, Canadian scientists are working on a new synthetic Tph1 enzyme blocker that will activate brown fat cells without dangerous CNS side effects..

medbe. en.