Modern science already allows you to grow muscle tissue, but scientists have never created tissue in the laboratory that can contract in response to electrical signals - the way it happens in nature, according to the online publication for girls and women from 14 to 35 years old Pannochka. net The other day, researchers from Duke University (USA) reported that this finally happened.

The technology of growing contractile muscle tissue is an amazing opportunity for medicine and pharmacology.

Imagine that it will be possible to test new drugs on lab-grown muscle tissue, for example.. But that's not all.

American scientists used myogenic precursors - cells that have passed the stage of stem cells, but have not yet turned into full-fledged muscle cells. They multiplied these cells 1,000 times and then placed them on a three-dimensional matrix filled with nutrient gel..

This whole structure was very similar to functional muscle fibers.. The resulting tissue retained functional signaling pathways and responded to electrical stimulation.. In addition, chemical signals (drugs) affected this tissue in the same way that real muscles should..

The results of the experiments showed a very high correlation, which suggests the imminent conduct of clinical trials and the introduction of technology into medical practice..

Here are some of the researchers' findings, published in eLife:.

“The resulting biomimetic constructs are similar to multinuclear striated muscle fibers with a pool of Pax7+ cells.. They contract spontaneously and respond to electrical stimuli with twitches and tetanic contractions..

Positive correlation between contraction strength and GCaMP6-mediated response allows for non-invasive monitoring of muscle fiber function and drug response.

Grown muscle fibers contain structurally and functionally mature acetylcholine receptors.

In response to the action of drugs, dose-dependent hypertrophy or toxic myopathy is observed, as occurs with real tissue.

The obtained human muscle fibers are a suitable platform for studying the effects of drugs, toxicological screening and developing new therapies for diseases of muscle tissue..

medbe. en.