Dihydrotestosterone - one of the representatives of the androgen group, a biologically active form of the testosterone hormone, which is formed due to the action of the enzyme 5-alpha-reductase in target cells.

Excess dihydrotestosterone in men causes baldness Dehydrotestosterone (DHT) is formed from free testosterone and androstenedione in androgen-dependent tissues. The main place of formation and secretion of testosterone is Leydig cells (interstitial cells of the testicles). The biosynthesis of the hormone is also carried out in the adrenal cortex.. The testosterone conversion process is facilitated by the tissue enzyme 5-alpha-reductase. Acting on testosterone in target cells (muscles, skin, adipose tissue), it adds two hydrogen atoms to the testosterone structure. Under the action of enzyme systems, the activity of testosterone increases, it begins to convert into 5? -dihydrotestosterone.

Dihydrotestosterone deficiency in women is characterized by a decrease in muscle mass, mood lability, a tendency to depression, a decrease in libido, a decrease in skin tone and thickness.

The testosterone metabolite is found in many tissues of the body (in the prostate gland, external genitals, seminal vesicles, some areas of the skin, hair follicles). Converted dehydrotestosterone has a more significant androgenic effect than its original form - testosterone; according to a number of indicators, its androgenic activity in peripheral tissues is 3-4 times higher.

Functions of DHT in women and men The main functions of DHT in the male body are associated with the formation and development of the reproductive system and sexual characteristics.. Dihydrotestosterone in men has the following effects:.

stimulates spermatogenesis;

suppresses the secretion of luteinizing hormone in the anterior pituitary gland;

affects the functional maturation of gonadotropic cells in the adenohypophysis;

stimulates the development of the prostate gland and external genital organs in the prenatal period, promotes their growth in puberty;

forms secondary sexual characteristics;

regulates the structure and development of the skeletal system, the growth of muscle mass;

has a stimulating effect on the nervous system;

regulates libido;

responsible for the production of sebum;

affects hair follicles, is responsible for sexual hair growth.

DHT is also produced in the female body. The main source of dihydrotestosterone production in women is the adrenal cortex, ovarian cells, conversion from precursors of steroid hormones in the liver, muscles, skin and adipose tissue.

Functions of DHT in the female body:.

affects carbohydrate, protein, water-fat metabolism;

determines the development of the skeleton and skeletal muscles;

regulates sweating;

activates the sebaceous glands;

forms libido.

DHT norm The most significant increase in the level of dihydrotestosterone is observed in adolescence, the peak of its production falls on 25 years. With age, the secretion of the hormone gradually decreases..

In the case of functional disorders, it is possible to normalize the hormonal balance without medication by correcting the lifestyle.

Dihydrotestosterone norms:.

up to 10 years: 5-25 pg / ml in girls and 5-50 pg / ml in boys;

from 10 to 12 years: 24-450 pg / ml in girls, 5-50 pg / ml in boys;

from 13 to 18 years old: 24-450 pg / ml in girls and 250-700 pg / ml in boys;

from 18 to 50 years: 24-450 pg / ml in women and 250-990 pg / ml in men;

from 50 years: 10-181 pg / ml for women, 250-700 pg / ml for men.

Deviations in DHT secretion can lead to serious disruptions in the activity of various body systems..

Decreased levels of DHT Most often, low levels of the hormone are observed in men after 30-40 years..

Reasons for a decrease in DHT levels in men obesity;

diabetes;

5-alpha reductase deficiency;

androgen deficiency;

hypogonadism (failure of the sex glands).

chronic prostatitis;

Morris syndrome (testicular feminization syndrome).

Symptoms of a decrease in DHT levels in men:.

female fat deposits (thighs, buttocks);

delayed puberty in adolescents, disproportionate limb growth;

development of a figure in female proportions;

reduced size of the penis, its abnormal structure;

slow growth of hair on the face, groin, armpits;

depression, emotional lability;

fast fatiguability;

lack of muscle mass;

impotence, decreased sex drive;

reproductive disorders, changes in spermogram.

Pathologies of the pituitary gland, ovaries, adrenal glands, diseases accompanied by a deficiency of adipose tissue can lead to the development of androgen deficiency states in women. DHT deficiency in women is characterized by a decrease in muscle mass, mood lability, a tendency to depression, a decrease in libido, a decrease in skin tone and thickness.

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