Oncogene magazine reports on a new protein that is responsible for the spread of cancer, according to Pannochka, an online publication for girls and women from 14 to 35 years old.. net Study results will help treat invasive breast cancer.

Despite public campaigns and scientific advances, breast cancer remains the second leading cause of cancer death in women, second only to lung cancer..

The main weapon of the deadly disease is rapid growth and the ability to quickly form metastases.. In the United States, 6 to 10% of cases are diagnosed as early as metastatic cancer, leaving little chance of a cure..

New research brings us closer to understanding the mechanism of metastases formation.

“A better understanding of the mechanisms underlying metastatic spread of breast cancer is critical to improving treatment,” says Dr. Ainhoa \u200b\u200bMielgo of the University of Liverpool Cancer Research Unit..

Insulin-like growth factor in cancer development.

Dr. Mielgo and her colleagues have long observed how immune cells macrophages interact with growing tumors.. Macrophages abound in the microenvironment of tumors, and these immune cells can either stop or promote the spread of breast cancer.

In the course of their research, British scientists were guided by the results of previous work.. In certain types of cancer, macrophages secrete a large number of so-called insulin-like growth factors - the real fuel for cells..

Insulin-like growth factors IGF-1 and IGF-2 are found in our blood, but in breast cancer, macrophages secrete enough growth factors to stimulate tumor metastasis to the lungs. This is proven experimentally.

Examining a group of patients with breast cancer, Dr. Mielgo found that in 75% of patients, IGF receptors were overly active, and the activity of the receptors was directly proportional to the infiltration of macrophages and the degree of tumor development..

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IGF blockers can help treat breast cancer.

Experiments in mice show that IGF blockers in combination with the chemotherapy drug paclitaxel significantly improve the results of breast cancer treatment.

“The addition of IGF blockers to standard chemotherapy led to a significant suppression of tumor cell proliferation and prevented the formation of metastases in the lungs,” stated Dr. Mielgo in her publication..

medbe. ru.