Paracetamol or aspirin: these drugs are similar, but differ in the regimen, mechanisms of action, safety and effectiveness for pain and temperature, according to Pannochka, an Internet publication for girls and women from 14 to 35 years old.. net Pain and fever are often associated with injury and illness.

These conditions strongly affect the daily life of people and require competent medical treatment..

Paracetamol and aspirin are some of the most popular antipyretic and pain relievers available over the counter without a prescription..

Paracetamol (acetaminophen) belongs to the group of non-narcotic pain relievers and antipyretics - analgesics-antipyretics. Available in the form of capsules, tablets, suppositories, suspensions, sachets, as well as in forms for intravenous administration.

Famous brands: Efferalgan, Panadol, Rapidol, Milistan, Tsefekon.

Paracetamol is part of numerous combined drugs for the symptomatic treatment of colds: Fervex, Pharmacitron, Coldrex, etc..

Aspirin (acetylsalicylic acid) belongs to the group of nonsteroidal anti-inflammatory drugs, or NSAIDs. Has a pronounced antipyretic and moderate analgesic and anti-inflammatory effect; prevents blood clots. Available in the form of tablets, there are no forms for intravenous administration.

Famous brands: Aspirin-Bayer, Upsarin, Asafen.

Acetylsalicylic acid can be found in combination preparations, including together with acetaminophen: citramone, citropak, askofen, askopar, etc..

How paracetamol and aspirin work?

Both drugs are used to relieve pain and fever..

They have a similar mechanism of action, affecting the central nervous system.. The main targets of both drugs are cyclooxygenases and prostaglandins. By blocking the action of prostaglandins in the brain, paracetamol and aspirin effectively normalize body temperature.

What is the Difference Between Aspirin and Paracetamol?

The first difference is that paracetamol has almost no anti-inflammatory effect.. The fact is that in the muscles and other peripheral tissues of the body, the action of the drug is blocked by special enzymes - peroxidases..

On the one hand, because of this, we are content with only the central effects - antipyretic and analgesic. On the other hand, due to the absence of a harmful effect on the mucous membrane of the stomach and intestines, paracetamol can be taken with gastritis.

The second difference is that aspirin inhibits the synthesis of thromboxanes - important molecules for the blood clotting process.. Therefore, long-term use of low doses of the drug reduces the risk of blood clots (myocardial infarction, ischemic stroke).

Unlike paracetamol, taking aspirin can cause bleeding.

When to take aspirin (Upsarin)?

The drug can be taken to relieve pain and inflammation caused by rheumatic conditions. Recommended for muscle pain, sprains, back pain, headache, toothache, and pain during menstruation.

Used for flu and cold symptoms in adults only.

In low doses, it is prescribed for the prevention of blood clots.

When to take Paracetamol (Panadol)?

Recommended for the relief of headache, toothache, joint, muscle and menstrual pain of mild to moderate intensity. Can be used as an antipyretic agent for febrile conditions in adults and children.

Who shouldn't take Upsarin?

Aspirin can cause problems such as ulceration of the gastric mucosa, bleeding, suffocation (\!

General contraindications:.

• Hypersensitivity to salicylates.

• Asthma provoked by NSAIDs and acetylsalicylic acid.

• Conditions predisposing to bleeding.

• Acute gastrointestinal ulcers.

• Hepatic or renal impairment.

• Heart failure Aspirin is dangerous when there is a deficiency of the enzyme glucose-6-phosphate dehydrogenase.

Who shouldn't take Panadol?

Paracetamol is recognized as the safest of this pair.. When taken in usual doses, rarely causes side effects. The main problem is hepatotoxic effect - liver damage when taking high doses.

The drug is well tolerated in asthma, gastritis and stomach ulcers.

In special forms, it is prescribed for children from 2 months of age!

General contraindications:.

• Alcoholism.

• Severe liver damage.

• Hepatic and renal failure.

• Blood diseases (severe anemia).

• Hypersensitivity Which drug is safe during pregnancy and lactation

Suppression of the synthesis of prostaglandins in peripheral tissues can negatively affect the development of the embryo and fetus, therefore, taking NSAIDs during pregnancy is undesirable.

Aspirin should not be taken during pregnancy, especially in the first and second trimester. In the third trimester, acetylsalicylic acid can cause premature closure of the ductus arteriosus and pulmonary hypertension.

At the end of pregnancy, the drug can inhibit uterine contractions.

Aspirin during lactation can be taken without exceeding the recommended doses and duration of treatment. The drug passes into breast milk in minimal amounts. Negative reactions from the child are not described.

Paracetamol during pregnancy can be taken at any time if the expected benefits outweigh the potential risks. In vivo studies did not reveal any abnormalities in fetal development or negative effects on the mother's body..

Paracetamol during lactation is considered a safe option for pain and temperature, if the recommended doses and duration of administration are strictly observed.

How to take paracetamol and aspirin correctly?

Paracetamol (Panadol).

The body breaks down most of the standard dose of paracetamol and excretes it in the urine. Part of the drug is transformed into a liver toxic by-product.

If you take Panadol in high doses or combine it with other medicines containing acetaminophen, the risk to the liver increases.

The average healthy adult should take no more than 4,000 mg of acetaminophen per day. For some people, doses of 3000 mg or more can cause problems, so do not exceed this figure..

Aspirin (Upsarin).

Adults and adolescents over 15 years old are allowed to take 300-900 mg of acetylsalicylic acid every 4-6 hours as needed.

The maximum daily dose of the drug should not exceed 4000 mg..

How Aspirin and Paracetamol Combine with Other Medicines?

Possible unwanted interactions of paracetamol:.

• Warfarin.

• Isoniazid.

• Carbamazepine.

• Phenobarbital.

• Phenytoin.

• Diflunisal Keep in mind that pharmacies sell hundreds of preparations containing paracetamol in various combinations. Consult your doctor or pharmacist to avoid taking such medications at the same time.!

Possible unwanted interactions of aspirin:.

• Methotrexate.

• Diuretic drugs.

• ACE inhibitors (captopril, enalapril, etc..

• Warfarin and other anticoagulants.

• Beta blockers (atenolol, metoprolol, etc..

• Other non-steroidal anti-inflammatory drugs.

• Valproic acid (Depakine).

• Phenytoin and others.

Both drugs are not recommended to be combined with alcohol.!

What is better for pain and temperature?

For pain, paracetamol preferred due to better safety profile.

Only acetylsalicylic acid has anti-inflammatory effect.

As an antipyretic agent, you can choose any drug, depending on the tolerance. For pregnant women and children under 15 years of age, paracetamol - drug No. 1.

For asthma, gastritis, stomach ulcers, bleeding tendencies, or anticoagulant therapy, paracetamol is safer.

For severe liver disease, it is better to take aspirin.

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