We owe McCallum the indication that during tetany the lime content in the blood drops.. This indication was fully confirmed in the writings of later authors.. At my suggestion, Perelman investigated the effect of various types of endocrine insufficiency on the Ca content in the blood..

It turned out that a drop in Ca in the blood is observed only when the parathyroid glands are removed.. Several years ago I expressed in print the idea that Ca in the hormone of the parathyroid glands is its biologically active element, just like iodine in the hormone of the thyroid gland. Ca must be in this hormone in connection with some complex organic complex. Recently, Cruickshenck showed that during tetany, the content of colloidal calcium in the blood drops..

Very interesting data on the pathogenesis of parathyroid tetany were obtained in my laboratory by Perelman. He showed that in many cases in sexually mature males by castration it is possible to stop the phenomena of already developed parathyroid tetany. Implantation of testicular tissue in castrated and parathyroid animals restores tetanic symptoms. Castration, however, has no effect on the lime content in the blood.. It remains at the castration of tetanic animals as low as in the presence of the phenomena of parathyroid tetany.

The phenomena of tetany, therefore, depend not only on the loss of the inhibitory effects of calcium (in our opinion, the calcium increment of the parathyroid glands), established by Loeb, but also on the state of muscle tone and excitability of the neuromuscular apparatus, the regulation of which is apparently subordinate.

Further, it seemed very interesting to decide whether the calcium-increment of the parathyroid gland exerts its inhibitory effect on the executive organs only through the nervous system (hormonal-nervous connection) or directly, chemically, purely hormonal. To clarify this issue, I suggested to Dr. Perelmaiu to tackle the question of the effect of the blood of the heart and blood flowing from the thyroid apparatus (it is impossible to obtain isolated venous blood of the parathyroid glands) on the inhibitory function of calcium from phagocytosis.

The experiments gave a negative result: in both sera, the addition of calcium had exactly the same inhibitory effect on phagocytosis.

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