Scientists have proposed new data on the little-known role of Y-chromosome genes specific to men, which may explain why they suffer from various diseases, including Covid-19, differently than women.. The results were published in Scientific Reports by University of Montreal professor Christian Deshepper.

“Our discovery provides a better understanding of how male genes on the Y chromosome allow male cells to function differently,” says Deshepper, lead author of the study.. "

In his study, Deshepper performed a genetic manipulation that inactivated two male genes on the Y chromosome, altering several signaling pathways that play an important role in certain functions of cells of the genital organs.. For example, under stressful conditions, some of the mechanisms involved can influence how a person's heart cells protect themselves from stress..

Research has shown that these male genes perform their regulatory functions in an unusual way compared to the mechanisms used by most other genes on non-sex chromosomes.. Thus, instead of specifically activating certain genes by direct action at the genome level, the Y-chromosome seems to affect cellular functions by affecting protein production..

The discovery of these differences in function may partly explain why the function of genes in the male Y chromosome is still poorly understood, says Deshepper..

https: // www. medikforum. ru /.

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