Doctors from the University of Santa Barbara have created the world's first pill that allows you to deliver insulin to the body of diabetics without using injections, which should psychologically facilitate the intake of this hormone, as they told at a meeting of the US Pharmacists Association in Orlando, according to an online publication for. net “If we are talking about diabetes, it was extremely important for us to create oral delivery methods of insulin into the body. Today, diabetics are forced to inject insulin seven times a day, and this is often a big problem for them.. Psychological discomfort often leads to drug disruptions, complications and hospitalization, ”said Samir Mitragotri from the University of California, Santa Barbara (USA).

As the doctors explain, the main problem with the oral delivery of insulin to the body is that its molecules are easily destroyed by the digestive juices in the stomach and intestines, so scientists have been working for several decades to create means to protect the hormone molecules from the digestive system.

For the first time, Mitragotri and her colleagues were able to create tablets that can not only deliver insulin to the human body through the oral route, but also reduce the dose of the drug by learning how to create special “nanoplasters” that can attach to the intestinal wall.

These patches, packaged inside a protective capsule that protects them from acids of the gastric juice, have two functions - they prevent the decomposition of the insulin molecules hidden inside them and facilitate their penetration into the bloodstream through the walls of the small intestine.

According to Mitragotri, until these pills have been approved by regulatory authorities and they have yet to undergo clinical trials in animals and humans.. When such permits are obtained, scientists from the University of Santa Barbara will check whether it is possible to use such tablets with nanoplasters for the delivery of other drugs - growth hormones, antibodies and vaccines - which are also decomposed by enzymes and acids of the stomach and intestines.

aspekty. net.