Scientists from the Mossakov Medical Research Center at the Polish Academy of Sciences have developed a simple method for preparing three-dimensional models of keratin scaffolds that can be used to study tissue regeneration.

Tissue regeneration at the site of damage or wounds caused by burns or diseases such as diabetes is a challenge.. Regenerative medicine and tissue engineering require additional key ingredients, such as biocompatible scaffolds that will not be rejected by the body, and suitable cells, including various stem cells, that effectively replace damaged tissue without side effects. The framework should mimic the structure and biological function of the native extracellular matrix on the damage side for tissue regeneration.

A study published in Open Medicine presents the results of the development of three-dimensional cell cultures derived from rat keratin cell fibers. Cells demonstrated the ability to grow and form three-dimensional colonies on this basis for several weeks without morphological changes and without observed apoptosis.

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