Scientists from the Texas Institute of Biomedical Research (San Antonio, USA) have identified four genes in baboons monkeys that affect the level of " net This discovery may lead to the development of new drugs that reduce the risk of cardiovascular disease..

Dr. Laura Cox, a Texas Biomed geneticist, says: “Our results are crucial because they point to fundamentally new goals for drug therapy that can reduce coronary risk..

The discovered genes were previously associated with cancer, so we believe that cardiovascular diseases and some types of cancer may have common mechanisms. ”.

Study sponsored by US National Institute of Health. You can read more about the results of this work on the pages of the new issue of Journal of Lipid Research, which will be released in July..

Texas Biomed Scientists Genetically Screen An Isolated Baboon Colony of 1,500 to Find Close Relatives That Have Low Levels of Low Density Lipoproteins (LDL) in the Blood.

During the study, all animals were fed 7 days foods high in cholesterol.. Scientists then used the latest genetic sequencing technology to identify the genes responsible for low or high LDL in individuals.. They discovered four genes (TENC1, ERBB3, ACVR1B and DGKA) that influenced LDL. It turned out that all these genes are part of the same signaling pathway, important for cell life, and the destruction of these pathways provokes the emergence of some types of cancer.

It is well known that high LDL levels in most populations are a major indicator of coronary risk.. Despite 25 years of constant struggle to control cholesterol, cardiovascular disease (CVD) remains the leading cause of death in developed countries.. For example, in the United States, according to the American Heart Association, every fourth death in 2013 falls to CVD.

Diseases of the coronary arteries of the heart are diseases that result from the interaction between genetic and environmental factors (including diet). To understand why some people have high cholesterol and others low, just looking at their diet is not enough.. Genetic factors play a large role in this..

Why baboons? Research of this kind is very difficult to conduct in humans, because with a large-scale study it is impossible to control everything that a person eats. Scientists have chosen baboons because they have very similar genetics and physiology.

A new study suggests that taking control of these genes can take control of coronary risk, that is, create an effective preventive treatment. The next step in the work of scientists is to study the mechanism by which genes affect cholesterol metabolism. This will be the beginning of the development of new treatments for hypercholesterolemia. Researchers hope mechanisms will be studied in two years.

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