Scientists from the Perelman School of Medicine at the University of Pennsylvania found what they call the " According to a study published in Nature Cell Biology, activation of transcription factor 4 (ATF4) may be the key to defeating cancer.

While millions of body cells essentially commit suicide daily to protect us from potentially dangerous ones, cancer cells prefer to ignore the death signals sent by the immune system.. This new discovery can help stop them..

Scientists made a discovery by looking at ATF4 in human lymphoma, breast and intestinal cells growing in the laboratory, and also in mice with cancer. They found that ATF4 controls a chemical pathway that works with the MYC gene, which controls growth and allows cancer to take over when it mutates. Stopping it, cancer cells produce too much protein and stimulate their own death..

Experiment Results in Mice.

One of the co-authors of the study, Dr. Konstantinos Kumenis:.

“We learned that we need to go further to block the growth of the tumor so that the cancer cells cannot be easily saved.. Research Identifies Goal ”.

The target in question is ATF4 itself, where the two involved signal paths converge. ATF4 not only includes the genes required by MYC for growth, but also controls the rate at which cells produce proteins known as 4E-BP.

Researchers stopped ATF4 in mice, tumors continued to increase 4E-BP production, leading to cell death from stress. This had the effect of stopping intestinal tumors and lymphomas..

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