American scientists have clarified the relationship between psoriasis of varying severity and the risk of chronic kidney disease (CKD).

The results of the analysis of patient histories showed that the probability of chronic kidney disease in people with severe psoriasis is on average twice as high as in patients suffering from mild psoriasis (balanced OS 1.93 versus 0.99).

This was recently announced by Dr. Joel Gelfand, an expert in dermatology and epidemiology at the Perelman School of Medicine at the University of Pennsylvania (Philadelphia).

In the online version of BMJ, scientists noted that in their analysis they took into account gender, age, body mass index, duration of observations, taking non-steroidal anti-inflammatory drugs, as well as the presence of cardiovascular diseases, diabetes, hyperlipidemia in patients.

For their research, Dr. Gelfand and his team used data from The Health Improvement Network (THIN), an electronic database that UK general practitioners contribute to..

A total of 136 529 eligible patients aged 18 to 90 years who suffered from mild psoriasis and 7 354 patients with severe psoriasis were selected. For comparison, 689 702 patients without psoriasis were taken. For nest analysis, additional data from the Health Outcomes and Psoriasis Events (iHOPE) study was used, which included 8,731 patients with severe psoriasis aged 25 to 64 years.

The results of the nesting analysis were supported by questionnaires that were sent directly to the doctors who observed these patients..

The risk of chronic kidney disease in patients with psoriasis was:.

• Mild psoriasis: grade 0.89 (95% CI 0.72-1.10).

• Psoriasis of moderate severity: SOS 1.36 (95% CI 1.06-1.74).

• Severe psoriasis: grade 1.58 (95% CI 1.07–2.34).

Patients whose skin lesions in psoriasis occupied more than 3% of the skin surface had an even higher risk of chronic kidney disease.. Scientists noted that the risk of CKD is significantly higher in patients of relatively young age with severe psoriasis, but after 30 years the risk in this group is gradually reduced.

“Although these results are not unexpected, this report is the first to show such a significant association between psoriasis and CKD, and it is of great importance in connection with the prevalence of psoriasis in different populations,” said Dr. Kamiar Kalantar-Zadeh, a researcher at the department.

Dr. Kalantar-Zadeh says that perhaps the results of a new study will lead to changes in clinical practice very soon, including recommendations for screening for CKD for people with psoriasis.

In August of this year, Dr. Gelfand and his colleagues found that psoriasis is associated with an increased risk of nine diseases at once, including chronic diseases of the lungs, liver, peripheral arteries, as well as diabetes and rheumatic diseases.

“In the past, dermatologists did not see such a relationship, it has only recently become an important topic for discussion,” comments Dr. Wayne Gulliver of Memorial University of Newfoundland (Canada) in an interview with a Western medical publication..

Scientific studies published over the past decades have revealed a link between intestinal microflora and diseases of the immune system, obesity and atherosclerosis. In 1999, the journal Integrative Medicine published an article in which scientists substantiated the relationship between psoriasis and intestinal microbiocenosis.

Dr. Kalantar-Zadeh also says that patients with psoriasis and CKD often have impaired intestinal microbiocenosis. There is a theory that a violation of microflora leads to the absorption of more toxic substances in the intestine. Kalantar-Zade is sure that this is one of the aspects of the etiology of psoriasis in such patients.

medbe. ru.