The intrauterine exposure to the hardener for bisphenol A plastics can increase the risk of prostate cancer in the offspring in late life, according to Pannochka, an online publication for girls and women from 14 to 35 years old. net This is evidenced by the results of experiments on mice published in Endocrinology.

Naked laboratory mice with human prostate stem cells, which were supplemented with bisphenol A, were subjected to hormone therapy with estrogen..

33-36% of these mice eventually developed prostate cancer, while congeners who did not receive bisphenol A had a cancer rate of only 13%.

“The amount of bisphenol A received by the rodents was equivalent to what a modern Westerner receives daily, including pregnant women,” says Dr. Gail Prins of the University of Illinois at Chicago.

The first work that showed the connection.

Researchers say the work, which included 143 rodents, provides the first direct evidence that exposure to BPA during early development increases the risk of cancer in the human prostate tissue..

Dr Jacqueline Moline, a North Neck employee at Great Neck, says prostate cells are targets for bisphenol A, and early exposure to this toxin does predispose to cancer.

Dr. Moline in an interview with the American publication MedPage Today said: “This work is very important, and I think that it has a very elegant technique.. We cannot relate the results to people because this is only an animal model. But an attempt by scientists indicates that exposure to BPA at an early stage in life is unsafe. ”.

Study design.

In order to mimic the effects of BPA during embryonic development, mice were fed so much chemical to create the blood serum concentration observed in an average pregnant woman in the USA (0.39-1.35 ng / ml).

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Among the results of the experiment, the following can be distinguished:.

• BPA increases the expression of progenitor cells, and the effect is dose-dependent.

• Continuous exposure to BPA in vitro plus in vivo (250 mcg / kg) increases the likelihood of intraepithelial neoplasia of the prostate gland by 45% (P \u003c0.01).

• The frequency of intraepithelial neoplasia of the prostate gland (HG-PIN) and adenocarcinoma increases sharply from 13% in the control group to 33-36% in grafts that were exposed to bisphenol A (P \u003c0.05).

medbe. ru.