A high or above average BMI is often associated with cancer, diabetes, cardiovascular and other diseases.. New research by scientists from Flinders University points to the fact that being overweight can in some cases improve the chances of survival among patients with certain types of oncology..
Focusing on clinical trials of atesolizumab, a common immunotherapeutic drug for treating non-small cell lung cancer (NSCLC), Australian researchers have found improved drug responsiveness in individuals with a high body mass index (BMI).
Amazing result published by JAMA Oncology.
“This is an interesting result, and it increases the potential for further research with other cancers and other anti-cancer drugs.”. We need to further investigate the possible relationship between BMI and concomitant inflammation, which may help to understand the mechanisms underlying the paradoxical response to this form of cancer treatment..
Previous studies have explored a concept called the “paradox of obesity,” where obesity is associated with an increased risk of developing certain types of cancer and, contrary to intuition, can protect and provide great survival benefits for some people..
Our study provides new evidence to support the hypothesis that high BMI and obesity may be associated with a response to immunotherapy, ”said Dr. Ganessan Kichenadasse, lead researcher, medical cancer researcher at the Flinders Cancer Innovation Center.
Flinders researchers have discovered NSCLC in patients with high BMI (BMI? 25 kg / m2) in four clinical trials, a significant decrease in mortality was noted with atesolizumab, apparently receiving therapy with immune control inhibitors (IRI). Of the 1,434 participants studied in the Australian study, 49% were normal, 34% were overweight and 7% were obese.
Treatment options for this form of lung cancer are rapidly evolving and include ICIs, molecular targeting and chemotherapy. “While our study was only at a basic level and during treatment, we believe that it requires additional research into the potentially protective role of high BMI..
WHO estimates that at least 2.8 million people die each year from being overweight or obese. Overweight and obesity lead to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance.. The risk of developing coronary heart disease, ischemic stroke and type 2 diabetes is steadily increasing with an increase in body mass index (BMI) - an indicator of weight relative to height.
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