A team from Denmark and France gathered a group of volunteers aged 18-35 years. For 6 weeks, men took 600 milligrams of ibuprofen daily or used a placebo effect.

It turned out that after 2 weeks in all patients taking the drug, the level of lutropin (LH) increased, which in men is responsible for the functioning of testosterone, which produces interstitial cells of the testes. Such increases mean that ibuprofen has a negative effect on them, so that they do not produce a steroid necessary for spermatogenesis (production of spermatozoa). The authors of the PNAS publication emphasize that the levels of LH and ibuprofen in the plasma are positively correlated, but the testosterone-to-LH ratio falls.

In this situation, the pituitary gland tried to compensate for deficiencies, producing more other hormones. This led to a state of compensated hypogonadism; The testosterone level remained constant, but the body was overloaded.

Later, researchers used grafts (part of the dilution was exposed to ibuprofen). Thus, it has been demonstrated that the endocrine effect of Sertoli and Leydig cells is inhibited by transcriptional repression.

Scientists add that compensated hypogonadism can lead to a short-term decrease in spermatogenesis (and, consequently, to fertility). However, in their opinion, this is not the reason for initiating an alarm. However, the long-term use of ibuprofen may be a problem, for example, in the treatment of chronic diseases or in the treatment of athletes.

proman. com. ua.

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