Checking the level of hormone cisspeptin in early pregnancy, the doctor can judge the risk of miscarriage in the patient.

In a prospective study, women who had a miscarriage had a 60% lower level of cisspeptin than women who had babies and babies.

This was reported by the study author Ali Abbara of the Imperial College of London at a joint meeting of the Society of Endocrinology and the International Endocrinology Congress (ICE / ENDO), which was held in Chicago.

"Even in women who did not have symptoms of a threatening miscarriage, a single blood test for the hormone cisspeptine more reliably predicts the risk of miscarriage than the analysis for human chorionic gonadotropin (hCG)," Abbara said, adding that the ability to accurately identify women with a miscarriage threat could would improve the management of pregnancy.

The researchers found that cisspeptin, as well as Kiss1 - the gene that encodes it - is an extremely important link in the human reproductive cycle. Kisceptin is excreted by testicles in men and ovaries in women, as well as by the placenta during pregnancy.

Miscarriage usually occurs in the first trimester of pregnancy, and is usually associated with abnormalities of placentation. The level of cisspeptin during normal pregnancy increases significantly, and the deficit of this hormone can be associated with a violation of normal placentation.

To assess how the plasma concentration of cisspeptin is associated with the risk of miscarriage, Abbara and his colleagues analyzed a group of 949 pregnant women who had no signs of a threatening miscarriage. Women were observed during the first trimester, making blood tests for cispeptin and hCG. 899 women endured children, 50 cases of miscarriage.

Researchers have observed that the level of cisspeptin stably increases during normal gestation, continuing to increase during the first 14 weeks of pregnancy. On the other hand, the level of the beta-unit of human chorionic gonadotropin (beta-hCG) reached its peak at the 8th week, beginning to gradually decrease after this moment.

Scientists have found that the concentration of cisspeptin in blood plasma was on average 60% lower in those women who had a miscarriage. According to the researchers, this is a significant difference, which allows us to rely on a new method. The level of cispeptin was a good marker in determining the risk of miscarriage - in statistical analysis the area under the ROC curve was 0.90.

Women who had a miscarriage had an average of 36% less beta-hCG as compared with normal pregnancies, but the level of this hormone was not as strong as the predictive factor (the area under the ROC curve of 0.78).

"Future scientific work should evaluate the possibility of an alternative use of the analysis for cispeptin to identify women with a high risk of miscarriage," Abbara said.. Today, according to the scientist, infertility treatment clinics are trying to determine the risk of miscarriage in traditional ways, doing everything in their power, but do not have such a reliable tool as the analysis on cisspeptin.

medbe. en.

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