Regular physical activity is considered the key to the prevention of obesity, cardiovascular disease and diabetes mellitus.

It's not a secret to anyone that exercises are more beneficial for one person than for others.

Why is this happening?.

Japanese scientists managed to find the answer.

A study in mice and volunteers revealed that a high level of selenoprotein P - a protein secreted by the liver - is associated with a decrease in endurance and the effectiveness of exercise. Scientists called selenoprotein P "the driver of resistance to exercise".

Details of his research Dr. Hirofumi Misu (Hirofumi Misu) from the University of Kanazawa published in the pages of the scientific publication Nature Medicine.

Modern American recommendations say that if an adult is absent, in the absence of contraindications, moderate aerobic exercises should be practiced 150 minutes a week or by high intensity exercises of at least 75 minutes per week, most days.

Obviously, a single standard for everyone is not exactly the right approach. The body's response to intense physical exertion is individual and depends on many factors.

"We know that some people demonstrate a complete lack of a positive response to exercise. In the sense that the form does not improve with training. Also, 15-20% of patients with diabetes almost no hypoglycemic effect of training, "- write the authors.

The results of the last study suggest that the reason for the futility of training sometimes lies in the biochemistry of our body, and not at all in laziness or wrong technique.

To confirm the role of selenoprotein P in "resistance to exercise," Dr. Misu and his colleagues conducted a series of terrific experiments with rodents and volunteer people.

Selenoprotein P is associated with endurance of the body.

To begin with, scientists evaluated the effect of selenoprotein P on the endurance of the body in two groups of mice: the first was excreted with a genetic deficit of this protein, and the second was wild mice.

Both groups of animals were forced to practice on the treadmill for 30 minutes a day for a month.

It turned out that mice with a deficiency of selenoprotein P coped with the load twice as much as their wild relatives, and also responded much better to the hormone insulin.

If the animals were given selenoprotein P prior to training, their intensity of phosphorylation (production of cellular energy) in skeletal muscles. Accordingly, rodents were less able to cope with the loads.

Metabolic effects of training also proved to be much more modest.

There was another way to defeat the "resistance to exercise": disconnect the cell receptors LRP1, through which selenoprotein P affects the muscle tissue. In rodents with a genetically disconnected receptor, phosphorylation is enhanced, and the body responds to loads better.

Drugs or a new dope for athletes?.

In the next phase of the study, Dr. Misu tested the effects of selenoprotein P on a group of three dozen healthy women who had not done physical exercises before.

All participants for 8 weeks attended the class of aerobics, and scientists measured each maximum oxygen consumption - an important indicator of physical fitness.

It was found that the concentration of selenoprotein P at the beginning of training is inversely proportional to the maximum oxygen consumption at the end of the course. In other words, the higher the content of selenoprotein P in the blood, the lower the efficiency of exercise, all other things being equal.

This confirms that selenoprotein P and its cellular receptor LRP1 are valuable targets for drugs and gene therapy that could make the body more hardy.

Further research will help verify this. However, already today the idea of ??a unique medicine (or doping for athletes?) Is emerging, with which one can train at times more efficiently.

It is enough to "disconnect" selenoprotein P or its receptor in muscle cells!.

medbe. en.