Human immunoglobulin is normal for intravenous administration. Immunoglobulins are proteins that, by their functional activity, are antibodies. The human immunoglobulin molecule contains two identical light and two identical heavy chains. Heavy polypeptide chains have 5 variants that correspond to 5 structurally and functionally different classes of immunoglobulins: IgG, IgA, IgM, IgD, IgE, which cause complement activation, phagocytosis and antibody-mediated cytotoxicity, according to the Internet publication for girls and women from 14 to 35 years Pannochka. net The first in response to the introduction of an antigen (microbe) is synthesized immunoglobulins of class M. They perform a protective function in the initial phase of the development of the infectious process, destroying bacteria, promoting faster capture and digestion by phagocytes and neutralizing microbial toxins.

The drug is obtained from healthy donors, is released in 25 ml vials, injected once a week, the course - 2 injections.

Levamisol (decaris) is a synthetic immunomodulator. This is a crystalline substance, the levorotatory isomer of tetra-mizol, which does not directly affect bacteria, viruses, fungi, but provides the body's resistance to bacterial and viral infection, especially in the state of immune depression. It has a positive effect only on patients with a moderate degree of immunological failure. Under the influence of levamisole, an earlier switching of IgM synthesis to IgG takes place with an increase in the concentration of all the major classes of immunoglobulins, as well as of C3 and C3-complement components. The immunostimulatory effect of levamisole is fully manifested only at certain optimal concentrations of the drug. Indications for use are cases of protracted course of mastitis, taking place against the background of a decrease in the activity of cellular immunity in cases of insufficient effectiveness of antibiotic therapy in the postoperative period. Side effects of levamisole are known, they disappear after discontinuation of the drug. The form of release - tablets (in 1 tablet of 150 mg). It is administered orally 1 tablet a day later. Total for the course of treatment 3 tablets (for 6 days).

In recent years, in the complex treatment of purulent diseases, including mastitis, a domestic preparation is used from the group of sulfopyrimidine derivatives - diucifone. The immunocorrective effect of this drug is diverse and depends primarily on the initial level of immunological reactivity. Dyuzifon selectively stimulates the regulatory function of T-lymphocytes, increasing their ability to secrete one of the central mediators of the immune system - interleukin-2, enhances the activity of NK cells. With a severe and moderate degree of immune deficiency to the 7th day after the first administration of the drug, there is an increase in the level of T-lymphocyte helper cells with a gradual increase in the absolute number of lymphocytes and a simultaneous decrease in the number of zero cells. Positive dynamics of immunity indicators is usually combined with the improvement of the clinical course of the disease. The drug is low in toxicity, the form of release is tightly clogged glass bottles containing 200 mg of dry sterile substance, or capsules containing 200 mg of active ingredient. Apply parenterally and per os. For parenteral use, the contents of the vial are diluted in 10 ml of sterile isotonic sodium chloride solution. To completely dissolve the preparation, the vial is placed in a container with water heated to 80-90 ° C, shaken, allowed to cool and injected intramuscularly. The course of treatment consists of 3-4 injections of the drug, which is administered every other day.

Tactivine is a nontoxic polypeptide preparation isolated from thymus calves. The most active fraction of it that is used in the clinic is AFT-6 (the activating factor of thymus-6). It is proved that the drug has an effect on the differentiation and maturation of T cells. Tactivine is used for a relatively rapid correction of the T-system of immunity. The effect of immunocorrection is noted already in the 1st day, reaching a maximum on the 7th-10th day. The drug normalizes the quantitative and functional indices of the T-system of immunity, increases the production of mediators, activates the function of T-helpers and T-killers, increases the ability of lymphocytes to RBTL, stimulates the production of lymphokines, including interferon. The effect of using tactotin for different severity of treatment for surgical infection is not the same and depends on the initial indices of immunological reactivity, t. of the degree of acquired immunodeficiency. Tactivin is available in 1 ml bottles. Subcutaneously administered once a day for 3-4 days.

Myelopid is a preparation of a polypeptide nature, obtained from a culture of bone marrow cells of pigs or calves. The drug stimulates the B-system of immunity, enhances anti-body formation when exposed to mature antibody-forming cells in the productive phase of the immune response, helps restore a number of other parameters of the humoral immune link. Form release - lyophilized powder in hermetically sealed flasks containing 0.003 g of the drug. The contents of the vial are diluted immediately before use in 1 ml of isotonic sodium chloride solution. Enter myelopid subcutaneously to 0,003 g daily. The course of treatment usually consists of 3 injections. The duration of treatment and the total dose depend on the clinical results and indices of the immune status.

In recent years, a drug polyoxidonium, which is a copolymer (N-oxide) -1,4-ethylene-piperazine and bromide (N-carboxyethyl) -1,4-ethylene-piperazine. The main target of the drug are macrophages, monocytes and neutrophils, and the main result of the action is an increase in phagocytosis. It promotes the expression of HLA-DR antigens, increases the enzymatic activity of phagocytic cells, the production of reactive oxygen species by neutrophils, monocytes and macrophages, and also increases their adhesion and chemotaxis. Produced in vials containing 6 mg of dry matter, which is dissolved in 2 ml of isotonic sodium chloride solution and administered subcutaneously or intramuscularly once a day. The course of treatment is 3-5 days health. sumy. ua.

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